SULT2A1 Recombinant Rabbit Monoclonal Antibody [JG36-18] (ET7108-26)

UNIPROT #

Q06520

PROTEIN NAME

SULT2A1

SYNONYMS

Alcohol/hydroxysteroid sulfotransferase antibody;Bile salt sulfotranasferase 2A1 antibody;Bile salt sulfotransferase antibody;Dehydroepiandrosterone sulfotransferase antibody;DHEA ST antibody;DHEA sulfotranasferase antibody;DHEA-ST antibody;DHEAS antibody;EC 2.8.2.14 antibody;Hst antibody;hSTa antibody;Hydroxysteroid sulfotransferase antibody;ST2 antibody;ST2A1 antibody;ST2A1_HUMAN antibody;ST2A3 antibody;STD antibody;sulfotranasferase, dehydroepiandrosterone-preferring antibody;Sulfotransferase 2A1 antibody;Sulfotransferase family 2A, dehydroepiandrosterone-preferring, member 1 antibody;Sulfotransferase family cytosolic 2A dehydroepiandrosterone (DHEA) preferring member 1 antibody;Sult2a1 antibody

SEQUENCE SIMILARITIES

Belongs to the sulfotransferase 1 family.

TISSUE SPECIFICITY

Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney.

POST-TRANSLATIONAL MODIFICATION

The N-terminus is blocked.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

The soluble sulfotransferases contribute to the elimination of xenobiotics, the activation of procarcinogens and the regulation of hormones. Members of the three groups comprising this superfamily show selectivity to certain substrate compounds. SULT1 sulfotransferases exhibit N-sulfating activities of carcinogenic heterocyclic amines, and are selective toward phenols, whereas SULT2 enzymes prefer hydroxysteroids and SULT3 family members are selective for N-substituted aryl and alicyclic compounds. SULT2A1 catalyzes the sulfonation of procarcinogen xenobiotics, hydroxysteroids and bile acids, and is highly expressed in adrenal and liver tissues. SULT2A1 plays a role in hepatic cholesterol homeostasis. SULT2B1 consists of two isoforms, SULT2B1a and SULT2B1b, which are transcribed from the same gene by alternative splicing of their first exons. Both isoforms are highly selective for the sulphation of 3b-hydroxysteroids such as pregnenolone, epiandrosterone, DHEA and androstenediol. SULT2B1b is expressed in prostate, skin, placenta and lung.