Glycerol Kinase Recombinant Rabbit Monoclonal Antibody [JE55-12] (ET7110-96)

UNIPROT #

P32189

PROTEIN NAME

Glycerol Kinase

SYNONYMS

ATP glycerol 3 phosphotransferase antibody;ATP:glycerol 3 phosphotransferase antibody;ATP:glycerol 3-phosphotransferase antibody;D930012N15Rik antibody;GK antibody;GK1 antibody;GKD antibody;GLPK_HUMAN antibody;Glycerokinase antibody;Glycerol kinase antibody;OTTHUMP00000023108 antibody;OTTHUMP00000023109 antibody;OTTHUMP00000215321 antibody

SEQUENCE SIMILARITIES

Belongs to the FGGY kinase family.

TISSUE SPECIFICITY

Highly expressed in the liver, kidney and testis. Isoform 2 and isoform 3 are expressed specifically in testis and fetal liver, but not in the adult liver.

SUBCELLULAR LOCATION

Mitochondrion outer membrane, cytoplasm.

FUNCTION

Glycerol kinase, encoded by the gene GK, is a phosphotransferase enzyme involved in triglycerides and glycerophospholipids synthesis. Glycerol kinase catalyzes the transfer of a phosphate from ATP to glycerol thus forming glycerol 3-phosphate. Adipocytes lack glycerol kinase so they cannot metabolize the glycerol produced during triacyl glycerol degradation. This glycerol is instead shuttled to the liver via the blood where it is: Phosphorylated by glycerol kinase to glycerol 3-phosphate. Converted from glycerol 3-phosphate to dihydroxyacetone phosphate (DHAP) via glycerol 3-phosphate dehydrogenase. DHAP can participate in glycolysis or gluconeogenesis. This protein may use the morpheein model of allosteric regulation. Glycerol Kinase (alternative name, ATP:glycerol 3-phosphotransferase or Glycerokinase) adopts a ribonuclease H-like fold consisting of an alpha-beta 2-layer sandwich of CATH family 3.30.420.40. As of March 2010, there were 20 structures of this protein in the PDB, most of which are homodimeric.