PPP1R1A Recombinant Rabbit Monoclonal Antibody [SN0756] (ET1611-60)

UNIPROT #

Q13522

PROTEIN NAME

PPP1R1A

SYNONYMS

I 1 antibody;I-1 antibody;I1 antibody;Inhibitor 1 antibody;IPP 1 antibody;IPP-1 antibody;IPP1 antibody;Ppp1r1a antibody;PPR1A_HUMAN antibody;Protein phosphatase 1 regulatory (inhibitor) subunit 1A antibody;Protein phosphatase 1 regulatory subunit 1A antibody;Protein phosphatase inhibitor 1 antibody

SEQUENCE SIMILARITIES

Belongs to the protein phosphatase inhibitor 1 family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation of Thr-35 is required for activity.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

The inhibitor of protein phosphatase 1 (IPP-1, I-1) plays a role in regulating the phosphorylation of other proteins, and is itself phosphorylated by a cyclic AMP-dependent protein kinase. IPP-1 is present in skeletal muscles and in distinct neuronal systems of the brain. The localization and expression of IPP-1 suggests that it may play discrete roles in certain regions and developing stages of the brain, independent of the regulation of protein phosphatase type 1 (PP-1). PP-1 binds to both phosphorylated and dephosphorylated IPP-1. Conversion of PP-1 to an Mn2+-dependent state appears to play a role in its regulation by IPP-1. IPP-1 attenuates the activity of glycogen phosphorylase and is thought to play an important role in the hormonal control of glycogen metabolism.