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Phospholamban Rabbit Polyclonal Antibody (HA500103)

Price: Regular price $315.00

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Catalog# HA500103

Rabbit Polyclonal to Phospholamban

Tested for

  • WB

  • IF-Cell

  • IHC-P

Reacts with

  • Human

  • Mouse

  • Rat

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

Phospholamban Rabbit Polyclonal Antibody (HA500103)

Immunogen

Synthetic peptide within human phospholamban aa 1-31.

Host

Rabbit

Positive Control

Rat heart tissue lysate, human heart tissue lysate, SH-SY5Y, rat heart tissue, human fetal skeletal muscle tissue, mouse heart tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071202

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IF-Cell

  • 1:50-1:100

  • IHC-P

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 6 kDa.

Isotype

IgG

TARGET

UNIPROT #

P26678

PROTEIN NAME

Phospholamban

SYNONYMS

Cardiac phospholamban antibody;CMD1P antibody;CMH18 antibody;PLB antibody;Pln antibody;PPLA_HUMAN antibody;PLN

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane, Mitochondrion membrane, Sarcoplasmic reticulum membrane, Membrane.

FUNCTION

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.

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