SLC8B1 Rabbit Polyclonal Antibody (ER1901-93)

UNIPROT #

Q6J4K2

PROTEIN NAME

SLC8B1

SYNONYMS

FLJ22233 antibody;Na(+)/K(+)/Ca(2+) exchange protein 6 antibody;Na(+)/K(+)/Ca(2+)-exchange protein 6 antibody;NCKX6 antibody;NCKX6_HUMAN antibody;NCLX antibody;Slc24a6 antibody;Sodium/potassium/calcium exchanger antibody;Sodium/potassium/calcium exchanger 6 antibody;Solute carrier family 24 (sodium/potassium/calcium exchanger) member 6 antibody;Solute carrier family 24 member 6 antibody

SEQUENCE SIMILARITIES

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.

TISSUE SPECIFICITY

Present in pancreatic beta-cells (at protein level).

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-258 by PKA prevents calcium overload.

SUBCELLULAR LOCATION

Membrane, Mitochondrion, Mitochondrion inner membrane.

FUNCTION

Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion . Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses . Required for store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity . Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange . In contrast to other members of the family its function is independent of K+ .