DCAMKL1 Recombinant Rabbit Monoclonal Antibody [JA11-03] (ET1704-10)

UNIPROT #

O15075

PROTEIN NAME

DCAMKL1

SYNONYMS

Calcium/calmodulin-dependent protein kinase type I-like CPG16 antibody;CL1 antibody;CLICK1 antibody;Cpg16 antibody;DCDC3A antibody;Dcl antibody;Dclk antibody;Dclk1 antibody;DCLK1_HUMAN antibody;Doublecortin domain-containing protein 3A antibody;Doublecortin-like and CAM kinase-like 1 antibody;Doublecortin-like kinase 1 antibody;KIAA0369 antibody;Serine/threonine-protein kinase DCAMKL1 antibody;Serine/threonine-protein kinase DCLK1 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

TISSUE SPECIFICITY

In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.

SUBCELLULAR LOCATION

Plasma membrane.

FUNCTION

Lissencephaly (smooth brain) is an abnormality of brain development characterized by incomplete neuronal migration and a smooth cerebral surface, manifesting as severe mental retardation. Genetic analysis has identified two proteins that are mutated in some cases of lissencephaly, designated lissencephaly-1 protein (LIS1) and doublecortin. LIS1 displays sequence homology to β-subunits of heterotrimeric G proteins, and doublecortin contains a consensus Abl phosphorylation site. In addition, the DCAMKL1 (doublecortinlike and CAM kinase-like 1) protein shows homology to doublecortin. All three proteins are highly expressed in developing brain and may function together to regulate microtubules involved in neuronal migration. The DCAMKL1 protein encodes a functional kinase that is capable of phosphorylating myelin basic protein and itself, but its kinase activity does not appear to affect its microtubule polymerization activity.