IKK gamma Recombinant Rabbit Monoclonal Antibody [JA11-83] (ET1704-40)

UNIPROT #

Q9Y6K9

PROTEIN NAME

IKK gamma

SYNONYMS

IkB kinase associated protein 1 antibody;IkB kinase subunit gamma antibody;Inhibitor of nuclear factor kappa B kinase subunit gamma antibody;AMCBX1 antibody;FIP 3 antibody;FIP-3 antibody;FIP3 antibody;Fip3p antibody;I kappa B kinase gamma antibody;I-kappa-B kinase subunit gamma antibody;IkB kinase gamma subunit antibody;IkB kinase subunit gamma antibody;IkB kinase-associated protein 1 antibody;Ikbkg antibody;IKK-gamma antibody;IKKAP1 antibody;IKKG antibody;IMD33 antibody;Incontinentia pigmenti antibody;Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase gamma antibody;Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase of, gamma antibody;Inhibitor of nuclear factor kappa-B kinase subunit gamma antibody;IP antibody;IP1 antibody;IP2 antibody;IPD2 antibody;NEMO antibody;NEMO_HUMAN antibody;NF kappa B essential modifier antibody;NF kappa B essential modulator antibody;NF-kappa-B essential modifier antibody;NF-kappa-B essential modulator antibody;ZC2HC9 antibody

TISSUE SPECIFICITY

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-68 attenuates aminoterminal homodimerization.; Polyubiquitinated on Lys-285 through 'Lys-63'; the ubiquitination is mediated by NOD2 and RIPK2 and probably plays a role in signaling by facilitating interactions with ubiquitin domain-containing proteins and activates the NF-kappa-B pathway. Polyubiquitinated on Lys-399 through 'Lys-63'; the ubiquitination is mediated by BCL10, MALT1 and TRAF6 and probably plays a role in signaling by facilitating interactions with ubiquitin domain-containing proteins and activates the NF-kappa-B pathway. Monoubiquitinated on Lys-277 and Lys-309; promotes nuclear export. Polyubiquitinated through 'Lys-27' by TRIM23; involved in antiviral innate and inflammatory responses. Linear polyubiquitinated on Lys-111, Lys-143, Lys-226, Lys-246, Lys-264, Lys-277, Lys-285, Lys-292, Lys-302, Lys-309 and Lys-326; the head-to-tail polyubiquitination is mediated by the LUBAC complex and plays a key role in NF-kappa-B activation. Deubiquitinated by USP10 in a TANK-dependent and -independent manner, leading to the negative regulation of NF-kappa-B signaling upon DNA damage.; Sumoylated on Lys-277 and Lys-309 with SUMO1; the modification results in phosphorylation of Ser-85 by ATM leading to a replacement of the sumoylation by mono-ubiquitination on these residues.; Neddylated by TRIM40, resulting in stabilization of NFKBIA and down-regulation of NF-kappa-B activity.; (Microbial infection) Cleaved by hepatitis A virus (HAV) protease 3C allowing the virus to disrupt the host innate immune signaling.; (Microbial infection) Polyubiquitinated on Lys-309 and Lys-321 via 'Lys-27'-linked ubiquitin by Shigella flexneri E3 ubiquitin-protein ligase ipah9.8, leading to its degradation by the proteasome.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.