Calcineurin A Recombinant Rabbit Monoclonal Antibody [JA64-11] (ET1704-02)

UNIPROT #

Q08209

PROTEIN NAME

Calcineurin A

SYNONYMS

Alpha isoform formerly PPP2B antibody;Calcineurin A alpha antibody;Calcineurin A1 antibody;CalcineurinA antibody;Calmodulin dependent calcineurin A subunit alpha isoform antibody;Calmodulin-dependent calcineurin A subunit alpha isoform antibody;CALN antibody;CALNA 1 antibody;CALNA antibody;CALNA1 antibody;CAM PRP catalytic subunit antibody;CAM-PRP catalytic subunit antibody;CCN 1 antibody;CCN1 antibody;CNA 1 antibody;CNA alpha antibody;CNA antibody;CNA1 antibody;PP2BA_HUMAN antibody;PPP2B antibody;Ppp3ca antibody;Protein phosphatase 2B catalytic subunit antibody;Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform antibody;Protein phosphatase 3 catalytic subunit alpha isoform PPP3CA antibody;Protein phosphatase 3 catalytic subunit alpha isozyme antibody;Serine/threonine protein phosphatase 2B catalytic subunit alpha isoform antibody;Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform antibody

SEQUENCE SIMILARITIES

Belongs to the PPP phosphatase family. PP-2B subfamily.

TISSUE SPECIFICITY

Expressed in keratinocytes (at protein level).

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm.

FUNCTION

In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunit have been identified, designated PP1, PP2A, PP2B and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4), is a putative member of a novel PP family. The PP2B family comprises subfamily members PP2B-Aα, PP2B-Aβ and PP2B-Aγ. Two additional regulatory subunits been identified, designated PP2B-B1 and PP2B-B2.