DUSP1 Recombinant Rabbit Monoclonal Antibody [JJ0930] (ET1701-82)

UNIPROT #

P28562

PROTEIN NAME

DUSP1

SYNONYMS

CL 100 antibody;CL100 antibody;Dual Specificity Phosphatase 1 antibody;Dual specificity protein phosphatase 1 antibody;Dual specificity protein phosphatase hVH1 antibody;DUS1_HUMAN antibody;DUSP 1 antibody;Dusp1 antibody;HVH1 antibody;MAP kinase phosphatase 1 antibody;Mitogen-activated protein kinase phosphatase 1 antibody;MKP-1 antibody;MKP1 antibody;Protein tyrosine phosphatase CL100 antibody;Protein-tyrosine phosphatase CL100 antibody;PTPN10 antibody;Serine/threonine specific protein phosphatase antibody;VH1 antibody

SEQUENCE SIMILARITIES

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

TISSUE SPECIFICITY

Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.