MUSK Recombinant Rabbit Monoclonal Antibody [PSH05-68] (HA722420)

UNIPROT #

O15146

PROTEIN NAME

MUSK

SYNONYMS

CMS9 antibody;FADS antibody;MDK 4 antibody;MDK4 antibody;MGC126323 antibody;MGC126324 antibody;Muscle antibody;Muscle associated receptor tyrosine kinase antibody;Muscle skeletal receptor tyrosine kinase antibody;Muscle skeletal receptor tyrosine protein kinase antibody;Muscle specific kinase receptor antibody;Muscle specific tyrosine kinase receptor antibody;Muscle specific tyrosine protein kinase receptor antibody;Muscle-specific kinase receptor antibody;Muscle-specific tyrosine-protein kinase receptor antibody;MuSK antibody;MUSK_HUMAN antibody;Neural fold somite kinase 1 antibody;Neural fold somite kinase 2 antibody;Neural fold somite kinase 3 antibody;Neural fold somite kinase1 antibody;Neural fold somite kinase2 antibody;Neural fold somite kinase3 antibody;Nsk 1 antibody;Nsk 2 antibody;Nsk 3 antibody;Nsk1 antibody;Nsk2 antibody;Nsk3 antibody;Receptor tyrosine kinase MuSK antibody;Skeletal muscle receptor tyrosine kinase antibody;skeletal receptor tyrosine-protein kinase antibody

SUBCELLULAR LOCATION

Postsynaptic cell membrane.

FUNCTION

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.