Fas / CD95 Recombinant Rabbit Monoclonal Antibody [JJ0942] (ET1701-92)

UNIPROT #

P25445

PROTEIN NAME

Fas(CD95)

SYNONYMS

ALPS 1A antibody;ALPS1A antibody;APO 1 antibody;Apo 1 antigen antibody;APO 1 cell surface antigen antibody;Apo-1 antigen antibody;APO1 antibody;Apo1 antigen antibody;APO1 cell surface antigen antibody;Apoptosis antigen 1 antibody;Apoptosis mediating surface antigen FAS antibody;Apoptosis-mediating surface antigen FAS antibody;APT 1 antibody;APT1 antibody;CD 95 antibody;CD 95 antigen antibody;CD95 antibody;CD95 antigen antibody;Delta Fas antibody;Delta Fas/APO 1/CD95 antibody;Delta Fas/APO1/CD95 antibody;Fas (TNF receptor superfamily, member 6) antibody;FAS 1 antibody;FAS 827dupA antibody;Fas AMA antibody;Fas antibody;FAS Antigen antibody;Fas cell surface death receptor antibody;FAS1 antibody;FASLG receptor antibody;FASTM antibody;sFAS antibody;Surface antigen APO1 antibody;TNF receptor superfamily, member 6 antibody;TNFRSF 6 antibody;TNFRSF6 antibody;TNR6_HUMAN antibody;Tumor necrosis factor receptor superfamily member 6 antibody

TISSUE SPECIFICITY

Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.

POST-TRANSLATIONAL MODIFICATION

Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane.; N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.

SUBCELLULAR LOCATION

Cell membrane, Secreted.

FUNCTION

The Fas receptor, also known as Fas, FasR, apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6), is a protein that in humans is encoded by the FAS gene.Fas was first identified using a monoclonal antibody generated by immunizing mice with the FS-7 cell line. Thus, the name Fas is derived from FS-7-associated surface antigen.The Fas receptor is a death receptor on the surface of cells that leads to programmed cell death (apoptosis) if it binds its ligand, Fas ligand (FasL). It is one of two apoptosis pathways, the other being the mitochondrial pathway.[8]