ERp57 Recombinant Rabbit Monoclonal Antibody [JM11-44] (ET1703-68)

UNIPROT #

P30101

PROTEIN NAME

ERp57

SYNONYMS

58 kDa glucose regulated protein antibody;58 kDa glucose-regulated protein antibody;58 kDa microsomal protein antibody;Disulfide isomerase ER 60 antibody;Disulfide isomerase ER-60 antibody;Endoplasmic reticulum resident protein 57 antibody;Endoplasmic reticulum resident protein 60 antibody;ER p57 antibody;ER protein 57 antibody;ER protein 60 antibody;ERp 57 antibody;ERp57 antibody;ERp60 antibody;ERp61 antibody;Glucose Regulated Protein 58 Kd antibody;GRP 57 antibody;GRP 58 antibody;GRP57 antibody;HsT17083 antibody;p58 antibody;PDIA 3 antibody;PDIA3 antibody;PDIA3_HUMAN antibody;Phospholipase C alpha antibody;PI PLC antibody;Protein disulfide isomerase A3 antibody;Protein disulfide isomerase family A member 3 antibody;Protein disulfide-isomerase A3 antibody

SEQUENCE SIMILARITIES

Belongs to the protein disulfide isomerase family.

TISSUE SPECIFICITY

Detected in the flagellum and head region of spermatozoa (at protein level).

SUBCELLULAR LOCATION

Endoplasmic reticulum lumen. Melanosome.

FUNCTION

Mammals defend themselves against intracellular pathogens through presentation of cytoplasmically-derived short pathogenic peptides to the cell surface of cytotoxic T lymphocytes, which subsequently leads to cytotoxic events with respect to the affected cell. Antigen presentation is mediated by major histocompatibility complex (MHC) class I molecules, which bind and coordinate short pathogenic peptides. MHC class I molecules assemble in the endoplasmic reticulum with chaperones before binding to the transporter associated with antigen processing (TAP). ERp57, also designated GRP57, GRP58, ERp60 and ERp61, is a component of the MHC class I pathway that appears to interact with MHC class I molecules before they associate with TAP. The human ERp57 gene maps to chromosome 15q15 and encodes a 505 amino acid protein. ERp57 has two Trp-Cys-Gly-His-Cys-Lys motifs completely conserved among the mammals. ERp57 may act as a protease, a protein disulfide isomerase, a phospholipase or a combination of these.