KPNB1 Recombinant Rabbit Monoclonal Antibody [PSH01-60] (HA721703)

UNIPROT #

Q14974

PROTEIN NAME

KPNB1

SYNONYMS

IMB 1 antibody;IMB1 antibody;IMB1_HUMAN antibody;Impnb antibody;Importin 90 antibody;Importin beta 1 antibody;Importin beta 1 subunit antibody;Importin subunit beta-1 antibody;Importin-90 antibody;IPOB antibody;Karyopherin beta 1 antibody;Karyopherin beta 1 subunit antibody;Karyopherin subunit beta-1 antibody;KPNB 1 antibody;Kpnb1 antibody;MGC2155 antibody;MGC2156 antibody;MGC2157 antibody;NTF 97 antibody;NTF97 antibody;NTF97/Importin beta antibody;Nuclear factor P97 antibody;Pore targeting complex 97 kDa subunit antibody;PTAC97 antibody

SUBCELLULAR LOCATION

Cytoplasm. Nucleus envelope.

FUNCTION

Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. In association with IPO7, mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.