AP2B1 Rabbit Polyclonal Antibody (HA500315)

UNIPROT #

P63010

PROTEIN NAME

AP2B1

SYNONYMS

Adapter related protein complex 2 beta 1 subunit antibody;Adapter-related protein complex 2 beta subunit antibody;Adaptin, beta 2 (beta) antibody;Adaptor protein complex AP-2 subunit beta antibody;Adaptor related protein complex 2, beta 1 subunit antibody;ADTB2 antibody;AP-2 complex subunit beta antibody;AP105B antibody;AP2 BETA antibody;Ap2b1 antibody;AP2B1_HUMAN antibody;Beta adaptin antibody;Beta-2-adaptin antibody;Beta-adaptin antibody;Beta2 adaptin antibody;CLAPB1 antibody;Clathrin assembly protein complex 2 beta large chain antibody;Clathrin associated/assembly/adaptor protein, large, beta 1 antibody;DKFZp781K0743 antibody;Plasma membrane adaptor HA2/AP2 adaptin beta subunit antibody

SUBCELLULAR LOCATION

Cell membrane, Coated pit, Membrane.

FUNCTION

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis.. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10.. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly.