ARF1 Recombinant Rabbit Monoclonal Antibody [SD2002] (ET1612-12)

UNIPROT #

P84077

PROTEIN NAME

ARF1

SYNONYMS

ADP Ribosylation Factor 1 antibody;ADP-ribosylation factor 1 antibody;ARF 1 antibody;ARF1 antibody;ARF1_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the small GTPase superfamily. Arf family.

POST-TRANSLATIONAL MODIFICATION

Demyristoylated by S.flexneri cysteine protease IpaJ which cleaves the peptide bond between N-myristoylated Gly-2 and Asn-3.

SUBCELLULAR LOCATION

Golgi apparatus, Cytoplasm, Cell junction , Membrane.

FUNCTION

ADP-ribosylation factors (ARFs), are small guanine nucleotide-binding proteins that enhance the enzymatic activities of cholera toxin, and constitute one family of the RAS superfamily. ARFs are essential and ubiquitous in eukaryotes, as they are involved in vesicular transport and functioning via phospholipase D activation. ARF proteins play a role in membrane traffic and organelle integrity and are intimately tied to their reversible association with membranes and distinct interactions with membrane phospholipids. ARF1 is regulated by the binding and hydrolysis of GTP. Coatomer, or COPI, is a heptameric protein recruited to membranes by ARF1. Research demonstrates that guanine nucleotide exchange-activated ARF1, when located at the Golgi membrane, recruits and binds cytoplasmic COPI to the membranes.