Dynamin 2 Recombinant Rabbit Monoclonal Antibody [JM61-38] (ET1705-2)

UNIPROT #

P50570

PROTEIN NAME

Dynamin 2

SYNONYMS

CMT2M antibody;CMTDI1 antibody;CMTDIB antibody;DI CMTB antibody;Dnm2 antibody;DYN II antibody;DYN2 antibody;DYN2_HUMAN antibody;Dynamin II antibody;Dynamin-2 antibody;Dynamin2 antibody;DynaminII antibody;DYNII antibody

SEQUENCE SIMILARITIES

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

TISSUE SPECIFICITY

Ubiquitously expressed.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-764 by CDK1 is greatly increased upon mitotic entry. It regulates cytokinesis downstream of calcineurin, and does not affect clathrin-mediated endocytosis. Dephosphorylated by calcineurin/PP2 (By similarity). Phosphorylated on tyrosine residues after activation of SRC (By similarity).

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Dynamin-2 is a protein that in humans is encoded by the DNM2 gene. Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Four alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.