Syntaxin 1a Recombinant Rabbit Monoclonal Antibody [JE54-37] (ET7110-68)

UNIPROT #

Q16623

PROTEIN NAME

Syntaxin 1a

SYNONYMS

HPC 1 antibody;Neuron specific antigen HPC1 antibody;Neuron-specific antigen HPC-1 antibody;OTTHUMP00000174615 antibody;OTTHUMP00000174616 antibody;OTTHUMP00000174617 antibody;OTTHUMP00000174618 antibody;P35-1 antibody;STX1 antibody;STX1A antibody;STX1A_HUMAN antibody;SYN1A antibody;Syntaxin 1A (brain) antibody;Syntaxin 1A brain antibody;Syntaxin-1A antibody

SEQUENCE SIMILARITIES

Belongs to the syntaxin family.

TISSUE SPECIFICITY

Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by CK2 (By similarity). Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1.; Sumoylated, sumoylation is required for regulation of synaptic vesicle endocytosis.

SUBCELLULAR LOCATION

Cell membrane, synaptic vesicle membrane, synaptosome; Secreted.

FUNCTION

Syntaxin-1A is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. Syntaxin-1A is a key protein in ion channel regulation and synaptic exocytosis.