VAMP2 Recombinant Rabbit Monoclonal Antibody [JM11-00] (ET1703-50)

UNIPROT #

P63027

PROTEIN NAME

VAMP2

SYNONYMS

FLJ11460 antibody;RATVAMPB antibody;RATVAMPIR antibody;SYB antibody;SYB2 antibody;Synaptobrevin 2 antibody;Synaptobrevin-2 antibody;VAMP 2 antibody;VAMP-2 antibody;Vamp2 antibody;VAMP2_HUMAN antibody;Vesicle associated membrane protein 2 antibody;Vesicle-associated membrane protein 2 (synaptobrevin 2) antibody;Vesicle-associated membrane protein 2 antibody

SEQUENCE SIMILARITIES

Belongs to the synaptobrevin family.

TISSUE SPECIFICITY

Nervous system and skeletal muscle.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by PRKCZ in vitro and this phosphorylation is increased in the presence of WDFY2.; (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 76-Gln-|-Phe-77 bond and probably inhibits neurotransmitter release.; (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which probably hydrolyzes the 59-Lys-|-Leu-60 bond and inhibits neurotransmitter release. Note that humans are not known to be infected by C.botulinum type D.; (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 58-Gln-|-Lys-59 bond and probably inhibits neurotransmitter release.; (Microbial infection) Targeted and hydrolyzed by C.tetani tetanus toxin (tetX) which hydrolyzes the 76-Gln-|-Phe-77 bond and probably inhibits neurotransmitter release.

SUBCELLULAR LOCATION

Cell junction, Cell membrane, Cytoplasmic vesicle , Synapse, Synaptosome.

FUNCTION

Syntaxins were originally thought to be docking proteins, but have more recently been categorized as anchoring proteins that anchor themselves to the cytoplasmic surfaces of cellular membranes. Syntaxins have been shown to bind to various proteins involved in exocytosis, including VAMPs (vesicle-associated membrane proteins), NSF (N-ethylmaleimide-sensitive factor), SNAP 25 (synaptosomal-associated protein of 25 kDa), SNAPs (soluble NSF attachment proteins) and synaptotagmin. VAMPs, also designated synaptobrevins, including VAMP-1 and VAMP-2, and synaptotagmin, a protein that may function as an inhibitor of exocytosis, are vesicular proteins. SNAPs, including a- and γ-SNAP, are cytoplasmic proteins that bind to a membrane receptor complex composed of VAMP, SNAP 25 and syntaxin. SNAPs mediate the membrane binding of NSF, which is essential for membrane fusion reactions. An additional protein designated synaptophysin may regulate exo-cytosis by competing with SNAP 25 and syntaxins for VAMP binding.