EDG1 Recombinant Rabbit Monoclonal Antibody [JM10-66] (ET1703-27)

UNIPROT #

P21453

PROTEIN NAME

EDG1

SYNONYMS

CD363 antibody;CHEDG 1 antibody;CHEDG1 antibody;D1S3362 antibody;ECGF 1 antibody;ECGF1 antibody;EDG 1 antibody;EDG1 antibody;endothelial differentiation G protein coupled receptor 1 antibody;Endothelial differentiation G-protein coupled receptor 1 antibody;Endothelial differentiation sphingolipid G protein coupled receptor 1 antibody;FLJ58121 antibody;G protein coupled sphingolipid receptor antibody;g protein-coupled receptor edg-1 antibody;S1P receptor 1 antibody;S1P receptor Edg 1 antibody;S1P receptor Edg-1 antibody;S1P receptor Edg1 antibody;S1P(1) receptor antibody;S1P1 antibody;s1pr1 antibody;S1PR1_HUMAN antibody;sphingolipid g-protein-coupled receptor 1 antibody;Sphingosine 1 phosphate receptor Edg 1 antibody;Sphingosine 1 phosphate receptor EDG1 antibody;sphingosine 1- phosphate receptor 1 antibody;Sphingosine 1-phosphate receptor 1 antibody;Sphingosine 1-phosphate receptor Edg-1 antibody;Sphingosine 1phosphate receptor type 1 S1P1 antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 1 family.

TISSUE SPECIFICITY

Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.

POST-TRANSLATIONAL MODIFICATION

S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1PR1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). S1PR1 was originally identified as an abundant transcript in endothelial cells and it has an important role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and vascular maturation. In addition, S1PR1 signaling is important in the regulation of lymphocyte maturation, migration and trafficking. Like the other members of the GPCR family, S1PR1 senses its ligand from outside the cell and activates intracellular signal pathways that at last lead to cellular responses. The signal is transduced through the association of the receptor with different G proteins, which recruits a series of systems for downstream amplification of the signal.