Phospho-PKA R2 (S99) Recombinant Rabbit Monoclonal Antibody [SC54-04] (ET1610-29)

UNIPROT #

P13861

PROTEIN NAME

Phospho-PKA R2 (S99)

SYNONYMS

cAMP dependent protein kinase regulatory subunit alpha 2 antibody;cAMP dependent protein kinase regulatory subunit RII alpha antibody;cAMP dependent protein kinase type II alpha regulatory chain antibody;cAMP dependent protein kinase type II alpha regulatory subunit antibody;cAMP-dependent protein kinase type II-alpha regulatory subunit antibody;KAP2 antibody;KAP2_HUMAN antibody;MGC3606 antibody;PKR 2 antibody;PKR2 antibody;PRKA R2 antibody;PRKAR 2 antibody;PRKAR2 antibody;PRKAR2A antibody;Protein kinase A RII alpha subunit antibody;Protein kinase cAMP dependent regulatory type II alpha antibody

SEQUENCE SIMILARITIES

Belongs to the cAMP-dependent kinase regulatory chain family.

TISSUE SPECIFICITY

Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by the activated catalytic chain.

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm.

FUNCTION

The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated Cα, Cβ and Cγ, that each represent specific gene products. Cα and Cβ are closely related (93% amino acid sequence similarity), whereas Cγ displays 83% and 79% similarity to Cα and Cβ, respectively. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus where it phosphorylates the transcription factor cAMP response element binding protein (CREB) on serine 133 which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the pol II transcription initiation complex.