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PKA C-alpha Recombinant Rabbit Monoclonal Antibody [PSH08-57] (HA723003)

Price: Regular price $385.00

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Catalog# HA723003

Rabbit Monoclonal to PKA C-alpha

Tested for

  • WB

  • IHC-P

  • IF-Cell

  • FC

  • IP

Reacts with

  • Human

  • Mouse

  • Rat

  • Monkey

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

PKA C-alpha Recombinant Rabbit Monoclonal Antibody [PSH08-57] (HA723003)

Immunogen

Recombinant protein within human pka c-alpha aa 1-351.

Host

Rabbit

Positive Control

HEK-293 cell lysate, PC-3 cell lysate, MCF7 cell lysate, PC-12 cell lysate, C6 cell lysate, COS-1 cell lysate, NIH/3T3 cell lysate, human brain tissue, human stomach tissue, human testis tissue, mouse testis tissue, rat testis tissue, MCF7, NIH/3T3, C6, HEK-293.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

PSH08-57

APPLICATION DILUTION

  • WB

  • 1:2,000

  • IHC-P

  • 1:200-1:1,000

  • IF-Cell

  • 1:50

  • FC

  • 1:1,000

  • IP

  • 1-2μg/sample

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 41 kDa

Isotype

IgG

TARGET

UNIPROT #

P17612

PROTEIN NAME

PKA C-alpha

SYNONYMS

cAMP-dependent protein kinase catalytic subunit alpha;PKA C-alpha;PRKACA;PKACA

SUBCELLULAR LOCATION

Cytoplasm, Cell membrane, Membranem Nucleus, Mitochondrion.

FUNCTION

The catalytic subunit α of protein kinase A is a key regulatory enzyme that in humans is encoded by the PRKACA gene. This enzyme is responsible for phosphorylating other proteins and substrates, changing their activity. Protein kinase A catalytic subunit (PKA Cα) is a member of the AGC kinase family (protein kinases A, G, and C), and contributes to the control of cellular processes that include glucose metabolism, cell division, and contextual memory. PKA Cα is part of a larger protein complex that is responsible for controlling when and where proteins are phosphorylated. Defective regulation of PKA holoenzyme activity has been linked to the progression of cardiovascular disease, certain endocrine disorders and cancers.

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