PDE6 alpha Rabbit Polyclonal Antibody (HA500264)

UNIPROT #

P16499

PROTEIN NAME

PDE6 alpha

SYNONYMS

5''-cyclic phosphodiesterase subunit alpha antibody;CGPR A antibody;GMP PDE alpha antibody;GMP-PDE alpha antibody;PDE 6 alpha antibody;PDE 6A antibody;PDE V B1 antibody;PDE V-B1 antibody;PDE6A antibody;PDE6A_HUMAN antibody;PDEA antibody;Phosphodiesterase 6 alpha antibody;Phosphodiesterase 6A alpha subunit antibody;Phosphodiesterase 6A antibody;Phosphodiesterase 6A cGMP specific rod alpha antibody;Retinal Rod Photoreceptor cGMP Phosphodiesterase alpha antibody;Rod cGMP specific 3' 5' cyclic phosphodiesterase alpha subunit antibody;Rod cGMP-specific 3'' antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.