CACNA1C Rabbit Polyclonal Antibody (ER1803-49)

UNIPROT #

Q13936

PROTEIN NAME

CACNA1C

SYNONYMS

alpha-1 polypeptide antibody;cardiac muscle antibody;isoform 1 antibody;L type antibody;CAC1C_HUMAN antibody;CACH 2 antibody;CACH2 antibody;CACN 2 antibody;CACN2 antibody;CACNA1C antibody;CACNL1A1 antibody;Calcium channel antibody;Calcium channel cardic dihydropyridine sensitive alpha 1 subunit antibody;Calcium channel L type alpha 1 polypeptide isoform 1 cardiac muscle antibody;Calcium channel voltage dependent L type alpha 1C subunit antibody;CaV1.2 antibody;CCHL1A1 antibody;DHPR alpha 1 antibody;DHPR alpha 1 subunit antibody;LQT8 antibody;TS antibody;Voltage dependent L type calcium channel alpha 1C subunit antibody;Voltage dependent L type calcium channel subunit alpha 1C antibody;Voltage gated calcium channel alpha subunit Cav1.2 antibody;Voltage gated calcium channel subunit alpha Cav1.2 antibody;Voltage gated L type calcium channel Cav1.2 alpha 1 subunit, splice variant 10* antibody;Voltage-dependent L-type calcium channel subunit alpha-1C antibody;Voltage-gated calcium channel subunit alpha Cav1.2 antibody

SEQUENCE SIMILARITIES

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.

TISSUE SPECIFICITY

Detected throughout the brain, including hippocampus, cerebellum and amygdala, throughout the heart and vascular system, including ductus arteriosus, in urinary bladder, and in retina and sclera in the eye. Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation by PKA activates the channel. Elevated levels of blood glucose lead to increased phosphorylation by PKA.

SUBCELLULAR LOCATION

Plasma membrane.

FUNCTION

Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).