Estrogen Inducible Protein pS2 Recombinant Rabbit Monoclonal Antibody [JM37-86] (ET1705-85)

UNIPROT #

P04155

PROTEIN NAME

Estrogen Inducible Protein pS2

SYNONYMS

BCEI antibody;Breast cancer estrogen inducible protein antibody;Breast cancer estrogen inducible sequence antibody;Breast cancer estrogen-inducible protein antibody;D21S21 antibody;Gastrointestinal trefoil protein antibody;Gastrointestinal trefoil protein pS2 antibody;hP1.A antibody;HP1A antibody;HPS 2 antibody;HPS2 antibody;pNR 2 antibody;PNR-2 antibody;pNR2 antibody;Polypeptide P1.A antibody;Protein pS2 antibody;PS 2 antibody;pS2 antibody;pS2 protein antibody;TFF 1 antibody;TFF1 antibody;TFF1_HUMAN antibody;Trefoil factor 1 antibody

TISSUE SPECIFICITY

Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level).

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. pS2, also designated Md2, BCEI, TFF1 and pNR-2, is a trefoil protein that is highly expressed in normal gastric mucosa. pS2 has also been detected in a number of carcinomas including cancers of the breast, pancreas and stomach. pS2 is not present in normal breast tissue but is inducible by estrogen in MCF7 cells. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. The gene encoding pS2 maps to human chromosome 21q22.3.