MRP8/S100A8 Rabbit Polyclonal Antibody (R1706-20)

UNIPROT #

P05109

PROTEIN NAME

MRP8/S100A8

SYNONYMS

60B8Ag antibody;AI323541 antibody;B8Ag antibody;BEE11 antibody;CAGA antibody;Calgranulin-A antibody;Calprotectin L1L subunit antibody;Calprotectin, included antibody;CFAG antibody;CGLA antibody;Chemotactic cytokine CP-10 antibody;CP-10 antibody;Cystic fibrosis antigen antibody;L1Ag antibody;Leukocyte L1 complex light chain antibody;MA387 antibody;MIF antibody;Migration inhibitory factor-related protein 8 antibody;MRP-8 antibody;Myeloid-related protein 8 antibody;Neutrophil cytosolic 7 kDa protein antibody;NIF antibody;p8 antibody;Pro-inflammatory S100 cytokine antibody;Protein S100-A8 antibody;S100 calcium binding protein A8 (calgranulin A) antibody;S100 calcium binding protein A8 antibody;S100 calcium-binding protein A8 antibody;S100A8 antibody;S100A8/S100A9 complex, included antibody;S10A8_HUMAN antibody;Urinary stone protein band A antibody

SEQUENCE SIMILARITIES

Belongs to the S-100 family.

TISSUE SPECIFICITY

Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes. Under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis. Found in high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohn's disease, giant cell arteritis, cystic fibrosis, Sjogren's syndrome, systemic lupus erythematosus, and progressive systemic sclerosis. Involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea inclusions. Strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin cancers.

SUBCELLULAR LOCATION

Cell membrane. Cytoplasm. Secreted.

FUNCTION

The family of EF-hand type Ca2+-binding proteins includes Calbindin (previously designated vitamin D-dependent Ca2+-binding protein), S-100 α and β, Cal-granulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins) and the parvalbumin family members, including parvalbumin α and parvalbumin β (also designated oncomodulin). Calbindin, S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S-100 α and β are present in a variety of other tissues and Calbindin is present in intestine and kidney. Parvalbumin α is also found in fast-contracting/ relaxing skeletal muscle fibers and parvalbumin β is found in many tumor tissues as well as in the organ of Corti. Calbindin, S-100 proteins and parvalbulmins have all been detected in Leydig cells and the testis. These proteins are thought to play a role in hormone production and spermatogenesis. Calgranulin is expressed in macrophages and epithelial cells.