Neutrophil Elastase Recombinant Rabbit Monoclonal Antibody [JF098-6] (ET1702-78)

UNIPROT #

P08246

PROTEIN NAME

Neutrophil Elastase

SYNONYMS

Bone marrow serine protease antibody;ELA2 antibody;ELANE antibody;Elastase 2 antibody;Elastase 2 neutrophil antibody;Elastase neutrophil expressed antibody;Elastase-2 antibody;ELNE_HUMAN antibody;GE antibody;Granulocyte derived elastase antibody;HLE antibody;HNE antibody;Human leukocyte elastase antibody;Leukocyte elastase antibody;Medullasin antibody;NE antibody;Neutrophil elastase antibody;PMN E antibody;PMN elastase antibody;Polymorphonuclear elastase antibody;SCN1 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase S1 family. Elastase subfamily.

TISSUE SPECIFICITY

Bone marrow cells. Neutrophil.

SUBCELLULAR LOCATION

Cytoplasmic vesicle, phagosome

FUNCTION

Neutrophil Elastase (NE) is a serine protease that is expressed in bone marrow precursor cells, stored in peripheral blood granulocytes, and implicated in the progression of a variety of inflammatory diseases, including idiopathic pulmonary fibrosis, rheumatoid arthritis, adult respiratory distress syndrome and cystic fibrosis. In neutrophils, Neutrophil Elastase contributes largely to the proteolysis of phagocytosed proteins, the migration of neutrophils and the remodeling of tissues following injury. Neutrophil Elastase, which is also designated medullasin, is secreted into the extracellular matrix, where it is then capable of destroying connective tissue proteins, including elastin, proteoglycans and Type IV Collagens. Neutrophil Elastase also mediates proteolysis by cleaving proteins that are associated with the complement system, such as antithrombin and Fibrinogen. Additionally, Neutrophil Elastase functions as a potent platelet agonist, where it potentiates the aggregation, secretion and mobilization of calcium in response to cathepsin G binding to platelet surface receptors.