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Integrating network pharmacology and experimental models to identify notoginsenoside R1 ameliorates atherosclerosis by inhibiting macrophage NLRP3 inflammasome activation
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Aucubin Alleviates Intervertebral Disc Degeneration by Repressing NF-κB-NLRP3 Inflammasome Activation in Endplate Chondrocytes
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Gelsevirine ameliorates sepsis-associated encephalopathy by inhibiting the STING signalling-mediated pyroptosis pathway in microglia
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AT-533,a Hsp90 inhibitor,attenuates HSV-1-induced inflammation.
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HSP60 regulates the cigarette smoke-induced activation of TLR4-NF-κB-MyD88 signalling pathway and NLRP3 inflammasome
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Regulation of the AGEs-induced inflammatory response in human periodontal ligament cells via the AMPK/NF-κB/NLRP3 signaling pathway
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Fucoidan modulates SIRT1 and NLRP3 to alleviate hypertensive retinopathy: in vivo and in vitro insights
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Copper induced cytosolic escape of mitochondrial DNA and activation of cGAS-STING-NLRP3 pathway-dependent pyroptosis in C8-D1A cells
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Sevoflurane preconditioning improves neuroinflammation in cerebral ischemia/reperfusion induced rats through ROS-NLRP3 pathway
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Lactobacillus plantarum postbiotics trigger AMPK-dependent autophagy to suppress Salmonella intracellular infection and NLRP3 inflammasome activation
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Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps
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Oral Delivery of Mouse β-Defensin 14 (mBD14)-Producing Lactococcus lactis NZ9000 Attenuates Experimental Colitis in Mice
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Polydatin improves vascular endothelial function by maintaining mitochondrial homeostasis under high glucose conditions
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Hepatoprotective efficacy and interventional mechanism of panaxanediol saponins component in high-fat diet-induced NAFLD mice
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Sirt3 improves monosodium urate crystal-induced inflammation by suppressing Acod1 expression
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Dynamin-Related Protein 1 Is Involved in Mitochondrial Damage, Defective Mitophagy, and NLRP3 Inflammasome Activation Induced by MSU Crystals
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Voluven treatment could induce NLRP3 inflammasome-mediated pyroptosis of bone marrow-derived macrophages
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Ginsenoside Rh2 Inhibits NLRP3 Inflammasome Activation and Improves Exosomes to Alleviate Hypoxia-Induced Myocardial Injury
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Spinal voltage-gated potassium channel Kv1.3 contributes to neuropathic pain via the promotion of microglial M1 polarization and activation of the NLRP3 inflammasome
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The effect of NLRP inflammasome on the regulation of AGEs‐ induced inflammatory response in human periodontal ligament cells
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IL‐1β promotes IL‐17A production of ILC3s to aggravate neutrophilic airway inflammation in mice
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Dendrobium officinale polysaccharides protected against ethanol-induced acute liver injury in vivo and in vitro via the TLR4/NF-κB signaling pathway
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Tao Xu;Aizhong Wang
Spinal TLR4/P2X7 Receptor-Dependent NLRP3 Inflammasome Activation Contributes to the Development of Tolerance to Morphine-Induced Antinociception
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Inhibition of P2X7 Purinergic Receptor Ameliorates Cardiac
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Hesperidin Protects Against High-Fat Diet-Induced Lipotoxicity in Rats by Inhibiting Pyroptosis
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Supramolecular salicylic acid ameliorates rosacea-like eruptions by suppressing NLRP3-mediated inflammasome activation in mice
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Small molecule inhibitor CRT0066101 inhibits cytokine storm syndrome in a mouse model of lung injury
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Sodium chloride promotes macrophage pyroptosis and aggravates rheumatoid arthritis by activating SGK1 through GABA receptors Slc6a12
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Penthorum chinense Pursh extract ameliorates hepatic steatosis by suppressing pyroptosis via the NLRP3/Caspase‐1/GSDMD pathway
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Lactiplantibacillus plantarum Postbiotics Suppress Salmonella Infection via Modulating Bacterial Pathogenicity, Autophagy and Inflammasome in Mice
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Salidroside Ameliorates Macrophages Lipid Accumulation and Atherosclerotic Plaque by Inhibiting Hif-1α-Induced Pyroptosis
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Targeting NLRP3 Inflammasome Alleviates Synovitis by Reducing Pyroptosis in Rats with Experimental Temporomandibular Joint Osteoarthritis
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Wang Junli,et al
Huanglian Jiedu Decoction Inhibits LPS-induced Neuroinflammation and Attenuates the
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Contribution of diabetes mellitus to periodontal inflammation during orthodontic tooth movement
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The Molecular Mechanism of Quercetin Improving Cerebral Ischemia Injury by Regulating NLRP3 Inflammasome Mediated Pyroptosis Axis
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NLRP10 promotes AGEs-induced NLRP1 and NLRP3 inflammasome activation via ROS/MAPK/NF-κB signaling in human periodontal ligament cells
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Protective Effects of the Soluble Receptor for Advanced Glycation End-Products on Pyroptosis during Myocardial Ischemia-Reperfusion
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Coordination-Driven Nanomedicine Mitigates One-Lung Ventilation-Induced Lung Injury via Radicals Scavenging and Cell Pyroptosis Inhibition
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Irisin attenuates fine particulate matter induced acute lung injury by regulating Nod2/NF-κB signaling pathway
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Bletilla striata polysaccharides protect against ARDS by modulating the NLRP3/caspase1/GSDMD and HMGB1/TLR4 signaling pathways to improve pulmonary alveolar macrophage pyroptosis
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PD184352 exerts anti-inflammatory and antioxidant effects by promoting activation of the Nrf2/HO-1 axis
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HSP60 Regulates Monosodium Urate Crystal-Induced
Inflammation by Activating the TLR4-NF-κB-MyD88 Signaling
Pathway and Disrupting Mitochondrial Function
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Neuroprotective effects of Jie-du-huo-xue decoction on microglia pyroptosis after cerebral ischemia and reperfusion——From the perspective of glial-vascular unit
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Wang Yue,et al
Artemisinin attenuated ischemic stroke induced pyroptosis by inhibiting ROS/TXNIP/NLRP3/Caspase-1 signaling pathway
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Lai Yingying,et al
Dihydrocapsaicin suppresses the STING-mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap
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Lulu Tang , Dongdong Zhang , Yujing Zhang,et al
Vitamin D3 alleviates lung fibrosis of type 2 diabetic rats via SIRT3 mediated suppression of pyroptosis
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Liu Li,et al
Ghrelin suppresses hypoxia/reoxygenation-induced H9C2 cell pyroptosis via NLRP3
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Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm
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Li, Xin;Wang, Chunchun;Zhu, Jiang;Lin, Qian;Yu, Minjie;Wen, Jiashu;Feng, Jie;Hu, Caihong
Sodium Butyrate Ameliorates Oxidative Stress-Induced Intestinal Epithelium Barrier Injury and Mitochondrial Damage through AMPK-Mitophagy Pathway
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Zheng, X., Gong, T., Tang, C., Zhong, Y., Shi, L., Fang, X., Chen, D., & Zhu, Z.
Gastrodin improves neuroinflammation-induced cognitive dysfunction in rats by regulating NLRP3 inflammasome
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Oxytocin ameliorates high glucose- and ischemia/reperfusion-induced myocardial injury by suppressing pyroptosis via AMPK signaling pathway
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Wu Xinyi,et al
Oridonin attenuates liver ischemia–reperfusion injury by suppressing PKM2/NLRP3-mediated macrophage pyroptosis
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Formononetin alleviates acute pancreatitis by reducing oxidative stress and modulating intestinal barrier
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Dietary Zinc Ameliorates TNBS-Induced Colitis in Mice Associated with Regulation of Th1/Th2/Th17 Balance and NF-κB/NLRP3 Signaling Pathway.
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Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of
IκBα and blocking mitochondrial damage.
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Dehydromevalonolactone ameliorates liver fibrosis and inflammation by repressing activation of NLRP3 inflammasome