PBR Recombinant Rabbit Monoclonal Antibody [SA90-03] (ET1601-19)

UNIPROT #

P30536

PROTEIN NAME

PBR

SYNONYMS

Benzodiazapine receptor (peripheral) antibody;Benzodiazepine peripheral binding site antibody;BPBS antibody;BZRP antibody;DBI antibody;IBP antibody;Isoquinoline carboxamide-binding protein antibody;MBR antibody;mDRC antibody;Mitochondrial benzodiazepine receptor antibody;PBR antibody;PBS antibody;Peripheral benzodiazepine receptor antibody;Peripheral benzodiazepine receptor-related protein antibody;Peripheral type benzodiazepine receptor antibody;Peripheral-type benzodiazepine receptor antibody;pk18 antibody;PKBS antibody;PTBR antibody;Ptbzr antibody;PTBZR02 antibody;RATPTBZR02 antibody;translocator protein (18kDa) antibody;Translocator protein antibody;Tspo antibody;Tspo1 antibody;TSPOA_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the TspO/BZRP family.

TISSUE SPECIFICITY

Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.

SUBCELLULAR LOCATION

Mitochondrion membrane

FUNCTION

Translocator protein (TSPO) is an 18 kDa protein mainly found on the outer mitochondrial membrane. It was first described as peripheral benzodiazepine receptor (PBR), a secondary binding site for diazepam, but subsequent research has found the receptor to be expressed throughout the body and brain. In humans, the translocator protein is encoded by the TSPO gene. It belongs to a family of tryptophan-rich sensory proteins. Regarding intramitochondrial cholesterol transport, TSPO has been proposed to interact with StAR (steroidogenic acute regulatory protein) to transport cholesterol into mitochondria, though evidence is mixed. In animals, TSPO (PBR) is a mitochondrial protein usually located in the outer mitochondrial membrane and characterised by its ability to bind a variety of benzodiazepine-like drugs, as well as to dicarboxylic tetrapyrrole intermediates of the haem biosynthetic pathway. TSPO has many proposed functions depending on the tissue. The most studied of these include roles in the immune response, steroid synthesis and apoptosis.