Integrin beta 1 Rabbit Polyclonal Antibody (ER31001)

UNIPROT #

P05556

PROTEIN NAME

Integrin beta 1

SYNONYMS

beta1 integrin antibody;CD29 antibody;Fibronectin receptor subunit beta antibody;FNRB antibody;Glycoprotein IIa antibody;GP IIa antibody;GPIIA antibody;Integrin beta-1 antibody;integrin VLA-4 beta subunit antibody;Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) antibody;ITB1_HUMAN antibody;ITGB1 antibody;MDF2 antibody;MSK12 antibody;OTTHUMP00000019420 antibody;Very late activation protein, beta polypeptide antibody;VLA BETA antibody;VLA-4 subunit beta antibody;VLA-BETA antibody;VLAB antibody;VLAbeta antibody

SEQUENCE SIMILARITIES

Belongs to the integrin beta chain family.

TISSUE SPECIFICITY

Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle).

POST-TRANSLATIONAL MODIFICATION

The cysteine residues are involved in intrachain disulfide bonds.

SUBCELLULAR LOCATION

Cell membrane, cytoplasm

FUNCTION

Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. These and other integrin beta 1 complexes have been historically known as very late activation (VLA) antigens. Integrin beta 1 is expressed as at least four different isoforms. In cardiac muscle and skeletal muscle, the integrin beta-1D isoform is specifically expressed, and localizes to costameres, where it aids in the lateral force transmission from the Z-discs to the extracellular matrix. Abnormal levels of integrin beta-1D have been found in limb girdle muscular dystrophy and polyneuropathy.