IRF6 Recombinant Rabbit Monoclonal Antibody [SD202-6] (ET1612-36)

UNIPROT #

O14896

PROTEIN NAME

IRF6

SYNONYMS

Interferon regulatory factor 6 antibody;IRF 6 antibody;IRF-6 antibody;IRF6 antibody;IRF6_HUMAN antibody;LPS antibody;OFC 6 antibody;OFC6 antibody;OTTHUMP00000034677 antibody;OTTHUMP00000034678 antibody;PIT antibody;PPS antibody;PPS1 antibody;VWS antibody;VWS1 antibody

SEQUENCE SIMILARITIES

Belongs to the IRF family.

TISSUE SPECIFICITY

Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-α and β) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-α and interferon-β genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3γ p48 and IFN consensus sequence-binding protein (ICSBP).