SCF Recombinant Rabbit Monoclonal Antibody [SC61-06] (ET1610-77)

UNIPROT #

P21583

PROTEIN NAME

SCF

SYNONYMS

C kit ligand antibody;C-kit ligand antibody;Ckit ligand antibody;DCUA antibody;DFNA69 antibody;DKFZp686F2250 antibody;familial progressive hyperpigmentation 2 antibody;FPH2 antibody;FPHH antibody;KIT ligand antibody;Kitl antibody;KITLG antibody;KL 1 antibody;KL1 antibody;Mast cell growth factor antibody;MGF antibody;MGF stem cell factor antibody;SCF antibody;SCF_HUMAN antibody;SF antibody;SHEP7 antibody;sKITLG antibody;Soluble KIT ligand antibody;Steel factor antibody;steel, mouse, homolog of antibody;Stem cell factor antibody;Stem cell factor precursor antibody

SEQUENCE SIMILARITIES

Belongs to the SCF family.

DEVELOPMENTAL STAGE

Acts in the early stages of hematopoiesis.

POST-TRANSLATIONAL MODIFICATION

A soluble form (sKITLG) is produced by proteolytic processing of isoform 1 in the extracellular domain.; Found in two differentially glycosylated forms, LMW-SCF and HMW-SCF. LMW-SCF is fully N-glycosylated at Asn-145, partially N-glycosylated at Asn-90, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97 or Asn-118. HMW-SCF is N-glycosylated at Asn-118, Asn-90 and Asn-145, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97.; A soluble form exists as a cleavage product of the extracellular domain.

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, Secreted.

FUNCTION

Stem cell factor (SCF) is the ligand for the transmembrane tyrosine kinase receptor proto-oncogene c-Kit. SCF, also designated KL, MGF and SLF, is a pleiotropic cytokine that has two alternatively spliced forms, 248 and 220 amino acids in length in human and mouse systems, respectively. Both the larger form and the smaller form are cleaved to produce soluble forms. The smaller splice variant lacks the proteolytic cleavage site, between amino acids 149 and 177 of the larger SCF form. The larger form of SCF is expressed in fibroblasts, brain and thymus, while the smaller form is found in spleen, testis, placenta and cerebellum. The SCF ligand is essential for the development of germ cells, hematopoietic progenitor cells and melanocyte precursors. SCF can stimulate the proliferation of mature mast cells as well as the maturation and proliferation of immature mast cells.