YB1 Recombinant Rabbit Monoclonal Antibody [ST0432] (ET1609-10)

UNIPROT #

P67809

PROTEIN NAME

YB1

SYNONYMS

BP 8 antibody;CBF-A antibody;CCAAT binding transcription factor I subunit A antibody;CCAAT-binding transcription factor I subunit A antibody;CSDA2 antibody;CSDB antibody;DBPB antibody;DNA binding protein B antibody;DNA-binding protein B antibody;EFI-A antibody;Enhancer factor I subunit A antibody;MDR NF1 antibody;MGC104858 antibody;MGC110976 antibody;MGC117250 antibody;NSEP 1 antibody;NSEP1 antibody;Nuclease sensitive element binding protein 1 antibody;Nuclease-sensitive element-binding protein 1 antibody;p50 antibody;Q15905 antibody;Y-box binding protein 1 antibody;Y-box transcription factor antibody;Y-box-binding protein 1 antibody;YB 1 antibody;YB-1 antibody;YBOX1_HUMAN antibody;YBX 1 antibody;ybx1 antibody

SEQUENCE SIMILARITIES

Belongs to the YBX1 family.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated by RBBP6; leading to a decrease of YBX1 transcactivational ability.; In the absence of phosphorylation the protein is retained in the cytoplasm.; Cleaved by a 20S proteasomal protease in response to agents that damage DNA. Cleavage takes place in the absence of ubiquitination and ATP. The resulting N-terminal fragment accumulates in the nucleus (By similarity).

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Cytoplasmic granule, Secreted.

FUNCTION

Y-box binding protein YB-1 (also known as CCAAT-binding transcription factor, enhancer factor I subunit A and DNA-binding protein B) belongs to a family of multifunctional proteins which regulate both transcription and translation. Y-box proteins interact with a wide variety of nucleic acid structures to act as transcription factors and mRNA masking proteins. The modular structure of Y-box proteins includes a highly conserved N-terminal cold-shock domain (CSD, equivalent to the bacterial cold-shock proteins) and four basic C-terminal domains containing Arginine clusters and aromatic residues. YB-1 plays a role in cell proliferation as an activator of growth-associated gene expression. YB-1 is also a repressor of the cell death-associated gene FAS. YB-1 may play an important role in controlling cell survival by regulating the expression of cell growth-associated and death-associated genes.