Thrombomodulin Recombinant Rabbit Monoclonal Antibody [JB48-23] (ET7107-92)

UNIPROT #

P07204

PROTEIN NAME

Thrombomodulin

SYNONYMS

AHUS 6 antibody;AHUS6 antibody;BDCA 3 antibody;BDCA3 antibody;CD 141 antibody;CD141 antibody;CD141 antigen antibody;Fetomodulin antibody;Thbd antibody;THPH12 antibody;THRM antibody;Thrombomodulin antibody;TM antibody;TRBM_HUMAN antibody

TISSUE SPECIFICITY

Endothelial cells are unique in synthesizing thrombomodulin.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.; The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. This raises the speed of protein C activation thousandfold. Thrombomodulin-bound thrombin has procoagulant effect at the same time by inhibiting fibrinolysis by cleaving thrombin-activatable fibrinolysis inhibitor (TAFI, aka carboxypeptidase B2) into its active form. Thrombomodulin is a glycoprotein on the surface of endothelial cells that, in addition to binding thrombin, regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene (THBD) have also been reported to be associated with atypical hemolytic-uremic syndrome (aHUS). The antigen described as BDCA-3 has turned out to be identical to thrombomodulin. Thus, it was revealed that this molecule also occurs on a very rare (0.02%) subset of human dendritic cells called MDC2. Its function on these cells is unknown.