TIE-1 Rabbit Polyclonal Antibody (0804-11)

UNIPROT #

P35590

PROTEIN NAME

TIE-1

SYNONYMS

JKT 14 antibody;JTK14 antibody;TIE antibody;Tie1 antibody;TIE1_HUMAN antibody;Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1 antibody;Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains antibody;Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 antibody;Tyrosine protein kinase receptor Tie 1 antibody;Tyrosine-protein kinase receptor Tie-1 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.

TISSUE SPECIFICITY

Specifically expressed in developing vascular endothelial cells.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.

SUBCELLULAR LOCATION

Cell membrane. Membrane.

FUNCTION

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene. TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells and platelets. TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.