MSY2 Rabbit Polyclonal Antibody (R1510-36)

UNIPROT #

Q9Y2T7

PROTEIN NAME

MSY2

SYNONYMS

Contrin antibody;CSDA 3 antibody;CSDA3 antibody;Dbpc antibody;DNA binding protein C antibody;DNA-binding protein C antibody;FRGY2 homolog antibody;Germ cell specific Y box binding protein antibody;Germ cell-specific Y-box-binding protein antibody;MGC118270 antibody;MGC45104 antibody;MSY 2 antibody;MSY2 antibody;MSY2 homolog antibody;OTTMUSP00000006276 antibody;RGD1305068 antibody;Y box binding protein 2 antibody;Y-box-binding protein 2 antibody;YBOX2_HUMAN antibody;YBX 2 antibody;YBX2 antibody

TISSUE SPECIFICITY

Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Also observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary artery, myocardium, and skeletal muscle. Undetectable in epithelial cells in respiratory, gastrointestinal, and urogenital tracts. Up-regulated in various carcinomas and germ cell tumors (at protein level).

POST-TRANSLATIONAL MODIFICATION

Phosphorylated during oocyte maturation and dephosphorylated following egg activation. Phosphorylated in vitro by a kinase activity associated with testicular mRNPs. Dephosphorylation leads to a decrease in its affinity to bind RNA in vitro (By similarity).

SUBCELLULAR LOCATION

Cytoplasm, Nucleus

FUNCTION

MSY2 and YB-2 (MSY3,4) belong to the Y-box family of multifunctional proteins that regulate both transcription and translation. Y-box proteins interact with a wide variety of nucleic acid structures to act as transcription factors and mRNA masking proteins. The modular structure of Y-box proteins includes a highly conserved N-terminal cold-shock domain (CSD, equivalent to the bacterial cold-shock proteins) and four basic C-terminal domains containing arginine clusters and aromatic residues. MSY2 is expressed in testis and ovary where it may repress translation of parental mRNA. The gene encoding human MSY2 maps to chromosome 17p11.2-13.1. YB-2 (MSY3,4 in mouse) is also known as DNA binding protein A and is highly expressed in the testis, heart and muscle. MSY2 and YB-2 bind to the consensus sequence 5'-UCCAUCA-3' contained in the Y-box element.