DDX3 Rabbit Polyclonal Antibody (HA500093)

UNIPROT #

O00571

PROTEIN NAME

DDX3

SYNONYMS

ATP dependent RNA helicase DDX3X antibody;ATP-dependent RNA helicase DDX3X antibody;CAP Rf antibody;DBX antibody;DDX14 antibody;DDX3X antibody;DDX3X_HUMAN antibody;DEAD (Asp Glu Ala Asp) box polypeptide 3 X linked antibody;DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked antibody;DEAD box antibody;DEAD box protein 3 antibody;DEAD box protein 3 X-chromosomal antibody;DEAD box X isoform antibody;DEAD box, X isoform antibody;DEAD/H (Asp Glu Ala Asp/His) box polypeptide 3 antibody;DEAD/H box 3 antibody;DEAD/H box 3, X-linked antibody;Helicase like protein 2 antibody;Helicase-like protein 2 antibody;HLP2 antibody;X isoform antibody;X-chromosomal antibody

SUBCELLULAR LOCATION

Inflammasome, Centrosome, Cell membrane, Nucleus, Cytoplasm, Stress granule, Lamellipodium.

FUNCTION

The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants.