Pumilio 1 Recombinant Rabbit Monoclonal Antibody [JG37-75] (ET7108-13)

UNIPROT #

Q14671

PROTEIN NAME

Pumilio 1

SYNONYMS

HsPUM antibody;KIAA0099 antibody;PUM 1 antibody;PUM L1 antibody;Pum1 antibody;PUM1_HUMAN antibody;PUMH 1 antibody;PUMH antibody;PUMH1 antibody;pumilio homolog 1 (Drosophila) antibody;Pumilio homolog 1 antibody;Pumilio-1 antibody;Pumilio1 antibody;PUML 1 antibody;PUML1 antibody

TISSUE SPECIFICITY

Expressed in brain, heart, kidney, muscle, intestine and stomach. Not expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-714 promotes RNA-binding activity. Following growth factor stimulation phosphorylated at Ser-714, promoting binding to the 3'-UTR of CDKN1B/p27 mRNA.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs.