CD13 Rabbit Polyclonal Antibody (ER1803-74)

UNIPROT #

P15144

PROTEIN NAME

CD13

SYNONYMS

Alanyl (membrane) aminopeptidase antibody;Alanyl aminopeptidase antibody;Aminopeptidase M antibody;Aminopeptidase N antibody;AMPN_HUMAN antibody;ANPEP antibody;AP M antibody;AP N antibody;AP-M antibody;AP-N antibody;APN antibody;CD 13 antibody;CD13 antibody;CD13 antigen antibody;gp150 antibody;hAPN antibody;LAP 1 antibody;LAP1 antibody;Microsomal aminopeptidase antibody;Myeloid plasma membrane glycoprotein CD13 antibody;p150 antibody;PEPN antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M1 family.

TISSUE SPECIFICITY

Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.

POST-TRANSLATIONAL MODIFICATION

Sulfated.; N- and O-glycosylated.; May undergo proteolysis and give rise to a soluble form.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

CD13, or aminopeptidase N, is a type II transmembrane glycoprotein that is expressed on most cells of Myeloid origin, including monocytes, basophils, eosinophils, neutrophils and Myeloid leukemias. CD13 is also found on certain epithelial cells, fibroblasts and osteoclasts. CD13 acts as a zinc-binding metalloprotease that plays a role in digestion and may function in the inactivation of some regulatory peptides such as enkephalins. CD13 may play a role in the invasion of cancer cells by enhancing their invasive capacity and metastatic behavior. The activity of CD13 can be inactivated using specific inhibitors that evoke apoptosis of CD13-positive cancer cells. Basic fibroblast growth factor (bFGF) expression upregulates CD13 expression in human melanoma cells by activating both the Myeloid and the epithelial CD13 promoter.