P Glycoprotein Recombinant Rabbit Monoclonal Antibody [SN06-42] (ET1611-30)

UNIPROT #

P08183

PROTEIN NAME

P Glycoprotein

SYNONYMS

ABC20 antibody;ABCB1 antibody;ATP binding cassette, sub family B (MDR/TAP), member 1 antibody;ATP-binding cassette sub-family B member 1 antibody;CD243 antibody;CLCS antibody;Colchicin sensitivity antibody;Doxorubicin resistance antibody;GP170 antibody;MDR1 antibody;MDR1_HUMAN antibody;Multidrug resistance 1 antibody;Multidrug resistance protein 1 antibody;P glycoprotein 1 antibody;P gp antibody;P-glycoprotein 1 antibody;PGY1 antibody

SEQUENCE SIMILARITIES

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

TISSUE SPECIFICITY

Expressed in liver, kidney, small intestine and brain.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. It exists in animals, fungi, and bacteria, and it likely evolved as a defense mechanism against harmful substances. P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in liver cells where it pumps them into bile ducts, in the cells of the proximal tubule of the kidney where it pumps them into urinary filtrate (in the proximal tubule), and in the capillary endothelial cells composing the blood–brain barrier and blood-testis barrier, where it pumps them back into the capillaries.