Albumin Mouse Monoclonal Antibody [C5-A8] (EM1901-80)

UNIPROT #

P02768

PROTEIN NAME

Albumin

SYNONYMS

alb antibody;ALBU_HUMAN antibody;Albumin (32 AA) antibody;Albumin (AA 34) antibody;Albumin antibody;Analbuminemia antibody;Bisalbuminemia antibody;Cell growth inhibiting protein 42 antibody;DKFZp779N1935 antibody;Dysalbuminemic hyperthyroxinemia antibody;Growth inhibiting protein 20 antibody;HSA antibody;Hyperthyroxinemia dysalbuminemic antibody;PRO0883 antibody;PRO0903 antibody;PRO1341 antibody;Serum albumin antibody

SEQUENCE SIMILARITIES

Belongs to the ALB/AFP/VDB family.

TISSUE SPECIFICITY

Plasma.

POST-TRANSLATIONAL MODIFICATION

Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.; Glycated in diabetic patients.; Phosphorylated by FAM20C in the extracellular medium.; Acetylated on Lys-223 by acetylsalicylic acid.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc . Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli . Does not prevent iron uptake by the bacterial siderophore aerobactin .