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alpha Actinin Mouse Monoclonal Antibody [A1G2] (EM1901-52)

Price: Regular price $350.00

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Catalog# EM1901-52

Mouse Monoclonal to alpha Actinin

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

Reacts with

  • Human

  • Rat

This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Mouse monoclonal primary

Product Name

alpha Actinin Mouse Monoclonal Antibody [A1G2] (EM1901-52)

Immunogen

Recombinant protein within human actn1 aa 388-619 / 892.

Host

Mouse

Positive Control

HeLa cell lysate, A431 cell lysate, A549 cell lysate, MCF7 cell lysate, PC-12 cell lysate, C6 cell lysate, A431, SiHa, JAR, human lung tissue, human liver carcinoma tissue, human skin tissue, human breast tissue, human breast carcinoma tissue, human kidney tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

A1G2

RRID

AB_3068897

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IF-Cell

  • 1:50-1:100

  • IHC-P

  • 1:50-1:500

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

2ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 103 kDa

Isotype

IgG1

TARGET

UNIPROT #

P12814

PROTEIN NAME

alpha Actinin

SYNONYMS

actinin 1 smooth muscle antibody;Actinin alpha 1 antibody;actinin, alpha 1 antibody;ACTN 1 antibody;Actn1 antibody;ACTN1_HUMAN antibody;Alpha Actinin 1 antibody;Alpha actinin cytoskeletal isoform antibody;Alpha-actinin cytoskeletal isoform antibody;Alpha-actinin-1 antibody;BDPLT15 antibody;F actin cross linking protein antibody;F-actin cross-linking protein antibody;FLJ40884 antibody;FLJ54432 antibody;Non muscle alpha actinin 1 antibody;Non-muscle alpha-actinin-1 antibody

SEQUENCE SIMILARITIES

Belongs to the alpha-actinin family.

SUBCELLULAR LOCATION

Cell membrane, cytoskeleton, Z line, cell junction, ruffle.

FUNCTION

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

CITATIONS

  • Biao, T., Cai-Feng, H., Xiao-Hong, L., Xiao-Li, C., Wen-Bei, L., Jun, W., Chao, C., & Tao, Y.

    From Bowen disease to cutaneous squamous cell carcinoma: eight markers were verified from transcriptomic and proteomic analyses

  • Yu, C., Yue, Z., Shi, M., Jiang, L., Chen, S., Yao, M., Yu, Q., Wu, X., Zhang, H., Yao, F., Wang, C., Sun, H., & Li, J.

    An Intrapericardial Injectable Hydrogel Patch for Mechanical-Electrical Coupling with Infarcted Myocardium

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