GATA4 Recombinant Rabbit Monoclonal Antibody [JA11-41] (ET1704-32)

UNIPROT #

P43694

PROTEIN NAME

GATA4

SYNONYMS

ASD2 antibody;GATA 4 antibody;GATA binding protein 4 antibody;GATA-binding factor 4 antibody;gata4 antibody;GATA4_HUMAN antibody;MGC126629 antibody;Transcription factor GATA 4 antibody;Transcription factor GATA-4 antibody;Transcription factor GATA4 antibody;VSD1 antibody

POST-TRANSLATIONAL MODIFICATION

Methylation at Lys-300 attenuates transcriptional activity.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary; lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites.