TAZ Rabbit Polyclonal Antibody (HA500300)

UNIPROT #

Q9GZV5

PROTEIN NAME

TAZ

SYNONYMS

DKFZP586I1419 antibody;FLJ27004 antibody;FLJ45718 antibody;OTTHUMP00000215994 antibody;OTTHUMP00000215995 antibody;OTTHUMP00000215996 antibody;OTTHUMP00000216001 antibody;TAZ antibody;Transcriptional co activator with PDZ binding motif antibody;Transcriptional coactivator with PDZ binding motif antibody;Transcriptional coactivator with PDZ-binding motif antibody;WW domain containing transcription regulator 1 antibody;WW domain containing transcription regulator protein 1 antibody;WW domain-containing transcription regulator protein 1 antibody;WWTR 1 antibody;WWTR1 antibody;WWTR1_HUMAN antibody

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, Membrane, Nucleus.

FUNCTION

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis . The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ . WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation . In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation . Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.