Delta-catenin Recombinant Rabbit Monoclonal Antibody [JE75-34] (HA722438)

UNIPROT #

Q9UQB3

PROTEIN NAME

Delta-catenin

SYNONYMS

ARM-repeat protein antibody;Catenin (cadherin associated protein) delta 2 antibody;catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) antibody;Catenin delta 2 antibody;Catenin delta-2 antibody;CTND2_HUMAN antibody;CTNND 2 antibody;Ctnnd2 antibody;Delta catenin antibody;Delta-catenin antibody;GT 24 antibody;GT24 antibody;Neural plakophilin related arm repeat protein antibody;Neural plakophilin related armadillo repeat protein antibody;Neural plakophilin-related ARM-repeat protein antibody;Neural plakophilin-related, Neurojungin antibody;Neurojungin antibody;NPRAP antibody;T cell delta catenin antibody

SUBCELLULAR LOCATION

Nucleus, Cell junction, adherens junction, Cell projection, dendrite, Perikaryon.

FUNCTION

δ-Catenin is a subfamily of catenin proteins with ten armadillo-repeats and includes the proteins catenin delta-1 and catenin delta-2. Catenin delta-2 is expressed in the brain where it is important for normal cognitive development. Like β-catenin and γ-catenin, δ-catenins seem to interact with presenilins. These catenin-presenilin interaction have implications for cadherin function and regulation of cell-to-cell adhesion. While β-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-1 catenin has been implicated as a regulator of the NF-κB transcription factor. Palmitoylation of δ-catenin seems to coordinate activity-dependent changes in synaptic adhesion molecules, synapse structure, and receptor localizations that are involved in memory formation.