FGF2 Recombinant Rabbit Monoclonal Antibody [JM28-10] (ET1703-18)

UNIPROT #

P09038

PROTEIN NAME

FGF2

SYNONYMS

Basic fibroblast growth factor antibody;Basic fibroblast growth factor bFGF antibody;BFGF antibody;FGF 2 antibody;FGF B antibody;FGF-2 antibody;Fgf2 antibody;FGF2 basic antibody;FGF2_HUMAN antibody;FGFB antibody;Fibroblast growth factor 2 (basic) antibody;Fibroblast growth factor 2 antibody;Fibroblast growth factor, basic antibody;HBGF 2 antibody;HBGF-2 antibody;HBGF2 antibody;HBGH 2 antibody;HBGH2 antibody;Heparin binding growth factor 2 precursor antibody;Heparin-binding growth factor 2 antibody;Prostatropin antibody

SEQUENCE SIMILARITIES

Belongs to the heparin-binding growth factors family.

TISSUE SPECIFICITY

Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.; Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.

SUBCELLULAR LOCATION

Secreted, Nucleus.

FUNCTION

FGF2, also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. It binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins, themselves a family of closely related molecules. Fibroblast growth factor protein was first purified in 1975; soon thereafter three variants were isolated: 'basic FGF' (FGF2); Heparin-binding growth factor-2; and Endothelial cell growth factor-2. Gene sequencing revealed that this group is the same FGF2 protein and is a member of a family of FGF proteins. Like other FGF family members, basic fibroblast growth factor possess broad mitogenic and cell survival activities, and is involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. In normal tissue, bFGF is present in basement membranes and in the subendothelial extracellular matrix of blood vessels. It stays membrane-bound as long as there is no signal peptide.