Cystatin C Recombinant Rabbit Monoclonal Antibody [JJ09-16] (ET1701-72)

UNIPROT #

P01034

PROTEIN NAME

Cystatin C

SYNONYMS

AD 8 antibody;AD8 antibody;Amyloid angiopathy and cerebral hemorrhage antibody;ARMD11 antibody;bA218C14.4 (cystatin C) antibody;bA218C14.4 antibody;Cst 3 antibody;Cst3 antibody;CST3 protein antibody;Cystatin 3 antibody;Cystatin-3 antibody;Cystatin-C antibody;Cystatin3 antibody;CystatinC antibody;CYTC_HUMAN antibody;Epididymis secretory protein Li 2 antibody;Gamma trace antibody;Gamma-trace antibody;HCCAA antibody;HEL S 2 antibody;MGC117328 antibody;Neuroendocrine basic polypeptide antibody;Post gamma globulin antibody;Post-gamma-globulin antibody

SEQUENCE SIMILARITIES

Belongs to the cystatin family.

TISSUE SPECIFICITY

Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland.

POST-TRANSLATIONAL MODIFICATION

The Thr-25 variant is O-glycosylated with a core 1 or possibly core 8 glycan. The signal peptide of the O-glycosylated Thr-25 variant is cleaved between Ala-20 and Val-21.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Cystatin C is a cysteine (thiol) protease inhibitor that belongs to the type II cystatin gene superfamily and is the most abundant extracellular inhibitor of cysteine proteases. Cystatin C is a constitutively secreted, amyloidogenic protein, which forms a two-fold symmetric dimer and modulates both cysteine protease activity and the expression of class II MHC molecules. Expression of cystatin C is an indicator of kidney function and glomerular filtration rate. Mutations in the cystatin C gene can lead to protein aggregates, which are implicated in hereditary amyloid angiopathy (HCCAA) and cerebral hemorrhage. Although both wild-type and mutant cystatin C are capable of forming concentration dependent inactive dimers, mutant cystatin C dimerizes at lower concentrations and is more susceptible to serine proteases, which may facilitate aggregation. In neuronal cells, oxidative stress stimulates expression of cystatin C, which may positively regulate apoptosis.