CD133 Rabbit Polyclonal Antibody (ER31008)

UNIPROT #

O43490

PROTEIN NAME

CD133

SYNONYMS

AC133 antibody;Antigen AC133 antibody;CD133 antibody;CORD12 antibody;Hematopoietic stem cell antigen antibody;hProminin antibody;MCDR2 antibody;MSTP061 antibody;OTTHUMP00000217744 antibody;OTTHUMP00000217745 antibody;OTTHUMP00000217746 antibody;PROM1 antibody;PROM1_HUMAN antibody;Prominin I antibody;Prominin like 1 antibody;Prominin like protein 1 precursor antibody;Prominin mouse like 1 antibody;Prominin-1 antibody;Prominin-like protein 1 antibody;Prominin1 antibody;PROML1 antibody;RP41 antibody;STGD4 antibody

SEQUENCE SIMILARITIES

Belongs to the prominin family.

TISSUE SPECIFICITY

Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level).

POST-TRANSLATIONAL MODIFICATION

Isoform 1 and isoform 2 are glycosylated.; Acetylation at Lys-225, Lys-257 and Lys-264 by NAT8 and NAT8B may control PROM1 protein expression and its function in cell apoptosis.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene.