ID2 Mouse Monoclonal Antibody [A4-D4] (M1301-2)

UNIPROT #

Q02363

PROTEIN NAME

ID2

SYNONYMS

bHLHb26 antibody;Cell growth inhibiting gene 8 antibody;class B basic helix loop helix protein 26 antibody;Class B basic helix-loop-helix protein 26 antibody;DNA binding protein inhibitor ID 2 antibody;DNA binding protein inhibitor ID2 antibody;DNA-binding protein inhibitor ID-2 antibody;GIG 8 antibody;GIG8 antibody;Helix loop helix protein ID2 antibody;ID2 antibody;ID2_HUMAN antibody;ID2A antibody;ID2H antibody;Inhibitor of differentiation 2 antibody;Inhibitor of DNA binding 2 antibody;Inhibitor of DNA binding 2, dominant negative helix loop helix protein antibody;MGC26389 antibody

TISSUE SPECIFICITY

Highly expressed in early fetal tissues, including those of the central nervous system.

DEVELOPMENTAL STAGE

Found in most early fetal tissues but not in the corresponding mature tissues.

SUBCELLULAR LOCATION

Cytoplasm, nucleus.

FUNCTION

DNA-binding protein inhibitor ID-2, is an inhibitor of differentiation protein, which, along with ID1, ID3, and ID4, plays a key role in the regulation of lineage commitment, cell fate decisions, and in the timing of differentiation during neurogenesis, lymphopoiesis, and neovascularization (angiogenesis). ID-2 may be an inhibitor of tissue-specific gene expression.