15-PGDH Recombinant Rabbit Monoclonal Antibody [JE60-23] (HA720047)

UNIPROT #

P15428

PROTEIN NAME

15-PGDH

SYNONYMS

15 hydroxyprostaglandin dehydrogenase [NAD+] antibody;15 PGDH antibody;15-hydroxyprostaglandin dehydrogenase [NAD+] antibody;15-PGDH antibody;15PGDH antibody;Hpgd antibody;Hydroxyprostaglandin dehydrogenase 15 (NAD) antibody;NAD+ dependent 15 hydroxyprostaglandin dehydrogenase antibody;OTTHUMP00000218960 antibody;OTTHUMP00000219016 antibody;OTTHUMP00000219018 antibody;PGDH antibody;PGDH_HUMAN antibody;PGDH1 antibody;PHOAR1 antibody;Prostaglandin dehydrogenase 1 antibody;SDR36C1 antibody;Short chain dehydrogenase/reductase family 36C member 1 antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. Primary enzyme catalyzing the conversion of hydroxylated arachidonic acid species to their corresponding oxidized metabolites (Probable). Prostaglandin inactivation, catalyzes the first step in the catabolic pathway of the prostaglandins. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Has hydroxylated docosahexaenoic acid metabolites as substrates. Converts resolvins E1, D1 and D2 to their oxo products which represents a mode of resolvins inactivation and stabilizes their anti-inflammatory actions.