2B4 Rabbit Polyclonal Antibody (HA500263)

UNIPROT #

Q9BZW8

PROTEIN NAME

2B4

SYNONYMS

2B4 antibody;C9.1 antibody;CD244 antibody;CD244 antigen antibody;CD244 molecule antibody;CD244 molecule natural killer cell receptor 2B4 antibody;CD244 natural killer cell receptor 2B4 antibody;CD244_HUMAN antibody;F730046O15Rik antibody;h2B4 antibody;Ly90 antibody;NAIL antibody;Natural killer cell activation-inducing ligand antibody;Natural killer cell receptor 2B4 antibody;NK cell activation inducing ligand antibody;NK cell activation inducing ligand NAIL antibody;NK cell activation-inducing ligand antibody;NK cell type I receptor protein 2B4 antibody;NKR2B4 antibody;Nmrk antibody;Non-MHC restricted killing associated antibody;OTTHUMP00000027884 antibody;p38 antibody;signaling lymphocytic activation molecule 4 antibody;SLAM family, member 4 antibody;SLAMF4 antibody

SUBCELLULAR LOCATION

Cell membrane, Membrane.

FUNCTION

Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor . Activating function implicates association with SH2D1A and FYN . Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2. Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis . Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells. Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1. At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells. Involved in the regulation of CD8+ T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells. Inhibits inflammatory responses in dendritic cells (DCs) .